Anh 1989.

Methods	Study design: An open label randomized controlled trial Study dates: Feb to Dec 1989
Participants	Number: 41 enrolled Inclusion criteria: adults > 16 yr old with cerebral malaria (P. falciparum parasitaemia > 1000/mm3 and Glasgow Coma Scale of 14 or less not attributable to any cause other than malaria) Exclusions: not specified
Interventions	1. Artesunate: 60 mg intravenous (IV) at 0, 4, 24, and 48 h 2. Quinine: 20 mg/kg IV loading dose over 4 h at 0 h then 10 mg/kg IV every 8 h until able to swallow then 10 mg/kg by mouth every 8 h until day 7 Additional antimalarials: none reported
Outcomes	1. Death 2. Coma recovery time 3. Parasite clearance time of 50% 4. Parasite clearance time of 95%
Notes	Location: Vietnamese hospital Transmission: not specified Funding: Roche Asian Research Foundation supplied artesunate (personal communication from author)
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Personal communication with author: Random numbers table
Allocation concealment (selection bias)	High risk	Comment: Not done
Blinding (performance bias and detection bias) Objective outcomes: Death	Low risk	Comment: An open‐label trial is unlikely to bias an objective outcome like death
Blinding (performance bias and detection bias) Subjective outcomes: Others	High risk	Comment: An open label trial. No attempt was made to blind participants, providers or outcome assessors
Incomplete outcome data (attrition bias) All outcomes	Low risk	No losses to follow‐up occurred
Selective reporting (reporting bias)	Low risk	No evidence of selective reporting
Other bias	Low risk	No other bias identified