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. 2019 May 16;7:298. doi: 10.3389/fchem.2019.00298

Figure 1.

Figure 1

Requirement of the imidazolium ring structure for stemotoxic activity (A) Light microscopic images of hiPSCs after treatment of YM155 (50 nM) and 6 (50 nM) for 24 h (top), Structure of YM155 and 6 (bottom) (Scale bar = 300 μm). (B) FACS analysis for the cleaved caspase3 (C.Casp3) staining (left), Percentage of cleaved caspase 3 positive cells were presented as bar graph (right) (n = 3) (P < 0.05 (*)). (C) Fluorescence microscopic images of hiPSCs 24 h after 50 nM of YM155 or 6, stained for cleaved caspase3 (C.Casp3) with DAPI nuclear counterstaining (Scale bar = 50 μm). (D) Relative enzyme activity of caspase3 after treatment of indicated chemicals (n = 3) (P < 0.05 (***)) (E) Summary table of three YM155 analogs with chemical structures.