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. 2019 May 16;7:298. doi: 10.3389/fchem.2019.00298

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Copyright © 2019 Go, Lim, Jeong, Kwon, Chung, Lee, Kim, Suh, Son, Lee, Cha and Kim.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hydrogen bond acceptor distance markedly affects stemotoxic activity (A) FACS analysis for cleaved caspase3 after treatment of YM155 and YM155 analogs (50 nM), Chemical structures of YM155 analogs were presented below. (B) Percentage of cleaved caspase3-positive cells at indicative YM155 analogs (left) and number of carbon chain of alcohol group of each compound (right) (n = 4) was presented as bar graph (P < 0.01 (**), 0.0001 (****)). (C) Light microscopic images of hiPSC and differentiated cells (HASMC and SMC3) 24 h after treatment of indicated compounds (Scale bar = 300 μm). (D) Percentages of live cells (Annexin-V ^negative and 7-AAD ^negative population) after treatment of YM155 and 5s in hiPSCs (SES8: left) and SMC3 (right) were presented.