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. 2019 May 16;7:298. doi: 10.3389/fchem.2019.00298

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Copyright © 2019 Go, Lim, Jeong, Kwon, Chung, Lee, Kim, Suh, Son, Lee, Cha and Kim.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Nitrogen in the pyrazine ring of YM155 is a hydrogen bond acceptor, and crucial for stemotoxic activity (A) Light microscopic images (top) and FACS analysis for cleaved caspase3 staining after treatment of indicated compounds (5k, 5l, and 5m, 50 nM) (bottom) with chemical structure, Percentages of cleaved caspase3 positive cells were presented as bar graph (right) (n = 4) (Scale bar = 300 μm) (P < 0.01 (**), 0.001 (***)). (B) Immunoblotting analysis for PARP-1, cleaved caspase 3 (C.Casp 3) after treatment of indicative dose of compounds, α-tubulin for equal protein loading control. (C) FACS analysis for Annexin-V/7-AAD after indicative dose of YM155 and YM155 analogs in hESCs (left), Percentages of live cells were graphically presented (right).