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. 2019 May 16;7:298. doi: 10.3389/fchem.2019.00298

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Copyright © 2019 Go, Lim, Jeong, Kwon, Chung, Lee, Kim, Suh, Son, Lee, Cha and Kim.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Stemotoxic activity of 5m (A) FACS analysis for cleaved caspase3 and SSEA3 staining after treatment of YM155 or 5l (left), Percentages of cleaved caspase3⁺ cells were presented by bar graph (right) (n = 4) (P < 0.01 (**), 0.001 (****)). (B) FACS analysis for cleaved caspase3 and SSEA3 staining after treatment of 5m, Percentages of cleaved caspase3⁺ cells were presented by bar graph (right) (n = 4) (P < 0.05 (*)). (C) Net changes in intracellular calcium levels in response to a pharmacological agonist, ATP (20 μM) or membrane depolarization (75 mM K+) after treatment of indicated chemicals in the SMC3 cells.