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. 2019 May 16;7:298. doi: 10.3389/fchem.2019.00298

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Copyright © 2019 Go, Lim, Jeong, Kwon, Chung, Lee, Kim, Suh, Son, Lee, Cha and Kim.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hydrogen bond acceptors strongly influence the stemotoxic activity of YM155 analogs (A) Chemical backbone structure of YM155 analogs (left) and six YM155 analogs (right). (B) FACS analysis for Annexin-V/PI staining after treatment of indicated compounds, Percentages of live cells (Annexin-V ^negative and PI ^negative Cells) were presented as bar graph (right) (n = 6) (P < 0.05 (*), 0.0001 (****)). (C) FACS analysis for Annexin-V/7-AAD staining after indicative concentration of YM155 and YM155 analogs (5e or 5f) (left). Percentages of live cells (Annexin-V ^negative and 7-AAD ^negative Cells) were presented as bar graph (right). (D) Light microscopic images after treatment of 20 nM of YM155 and YM155 analogs (Scale bar = 500 μm). (E) Immunoblotting analysis for PARP-1 and cleaved caspase 3 (C.Casp3) after indicative concentration of YM155 analogs, α-tubulin for equal protein loading control.