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. 2019 May 16;7:298. doi: 10.3389/fchem.2019.00298

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Copyright © 2019 Go, Lim, Jeong, Kwon, Chung, Lee, Kim, Suh, Son, Lee, Cha and Kim.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Scheme 1 — Synthetic procedure of YM155 analogs Reagents and conditions (a) Et₃N, CH₂Cl₂, r.t. (b) Ac₂O, c-H₂SO₄, 80°C (c) RNH₂, Et₃N, CH₂Cl₂, r.t. or CHCl₃, reflux (for 5a, 5b) (d) HBr, EtOH, reflux.