Comparison 8. Live attenuated vaccines (all types) versus placebo ‐ Efficacy outcomes.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
8.1 Cases of cholera following natural infection ‐ CVD 103HgR versus placebo	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
8.1.1 First year after vaccination	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
8.1.2 Second year after vaccination	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
8.1.3 Third year after vaccination	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
8.2 Severe cholera following natural infection ‐ CVD 103HgR versus placebo	1	67508	Risk Ratio (M‐H, Fixed, 95% CI)	1.58 [0.61, 4.07]
8.3 Death from any cause (except motor accidents)	1	67508	Risk Ratio (M‐H, Fixed, 95% CI)	1.03 [0.83, 1.28]
8.4 Death from diarrhoea (any organism)	1	67508	Risk Ratio (M‐H, Fixed, 95% CI)	0.75 [0.26, 2.17]
8.5 Cases of moderate to severe diarrhoea ‐ following artificial challenge	3	108	Risk Ratio (M‐H, Fixed, 95% CI)	0.08 [0.02, 0.34]
8.5.1 CVD 103HgR	1	51	Risk Ratio (M‐H, Fixed, 95% CI)	0.09 [0.01, 0.67]
8.5.2 Peru 15	1	36	Risk Ratio (M‐H, Fixed, 95% CI)	0.05 [0.00, 0.79]
8.5.3 VC638	1	21	Risk Ratio (M‐H, Fixed, 95% CI)	0.15 [0.01, 2.86]
8.6 Cases of any diarrhoea ‐following artificial challenge	3	108	Risk Ratio (M‐H, Fixed, 95% CI)	0.14 [0.07, 0.28]
8.6.1 CVD 103HgR	1	51	Risk Ratio (M‐H, Fixed, 95% CI)	0.20 [0.09, 0.44]
8.6.2 Peru 15	1	36	Risk Ratio (M‐H, Fixed, 95% CI)	0.07 [0.01, 0.52]
8.6.3 VC638	1	21	Risk Ratio (M‐H, Fixed, 95% CI)	0.05 [0.00, 0.80]