Figure 1.

External pH modulates the transmembrane current and the plasma membrane potential of hTM cells. (A) A representative trace of the whole-cell current illustrating inhibition and potentiation of current by extracellular acidification and alkalinization. The cells were held at +100 (circles) and −100 mV (triangles); solid bars indicate the application time of the external solution with specified pH. (B) Current–voltage relationship of current recorded at time points shown in A. (C) Summary of experiments shown in A and B, with the average ± SEM of current amplitudes recorded at +100 (open bars) and −100 mV (patterned bars). **P < 0.01; Pair-sample t-test, n = 8 cells.