Wunderlich 1989.

Methods	Randomized controlled trial; 10 centres Duration: not stated
Participants	Inclusion criteria: adults with acute diarrhoea (characteristics and duration not stated). Exclusion criteria: not stated. 3 participants from each group withdrawn on day 4 or later (causes for dropouts stated to be unrelated to medication); 4 participants assigned to the probiotic group and 5 assigned to the placebo group did not complete the study (reasons not stated). Number completing study (for persisting diarrhoea outcomes): 40/47 (85.1%) in the probiotic group and 38/46 (82.6%) in the placebo group.
Interventions	Live Enterococcus SF 68 (Bioflorin; 225 x 106 bacteria/day for 7 days) Placebo Not stated when interventions started.
Outcomes	Number of cases cured by day of treatment (definition of cure not stated). No adverse events attributed to probiotic.
Notes	Study location: Switzerland and Lichtenstein (very low child and adult mortality). Cause of diarrhoea: no data presented. Nutritional status: no data presented. Hydration status: no data presented. Source of funding: not stated
Risk of bias
Bias	Authors' judgement	Support for judgement
Adequate sequence generation?	Unclear risk	Not described
Allocation concealment?	Unclear risk	Not described
Blinding? All outcomes	Low risk	identical placebo
Incomplete outcome data addressed? All outcomes	High risk	Follow up <90% in both groups

CFU: colony‐forming units
 IV: intravenous
 NCHS: National Centre for Health Statistics
 ORF: oral rehydration fluid
 RCT: randomized controlled trial
 SD: standard deviation