Comparison 2. Monthly sulfadoxine pyrimethamine (SP) compared to standard 2‐dose SP ‐ Best‐case scenario.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Maternal anaemia: haemoglobin less than 11 g/dl.	2	722	Risk Ratio (M‐H, Random, 95% CI)	0.66 [0.38, 1.16]
1.1 Primigravidae and secundigravidae	2	517	Risk Ratio (M‐H, Random, 95% CI)	0.71 [0.32, 1.55]
1.2 Multigravidae (greater than 2 pregnancies)	1	205	Risk Ratio (M‐H, Random, 95% CI)	0.58 [0.42, 0.80]
2 Low Birth Weight: birth weight less than 2.5 kg	2	722	Risk Ratio (M‐H, Random, 95% CI)	0.43 [0.24, 0.77]
2.1 Primigravidae and secundigravidae	2	517	Risk Ratio (M‐H, Random, 95% CI)	0.49 [0.23, 1.05]
2.2 Multigravidae	1	205	Risk Ratio (M‐H, Random, 95% CI)	0.32 [0.16, 0.61]
3 Neonatal mortality	2	722	Risk Ratio (M‐H, Random, 95% CI)	0.19 [0.10, 0.36]
3.1 Primigravidae and secundigravidae	1	266	Risk Ratio (M‐H, Random, 95% CI)	0.13 [0.04, 0.43]
3.2 Primigravidae, secundigravidae and multigravidae women	1	456	Risk Ratio (M‐H, Random, 95% CI)	0.22 [0.11, 0.47]
4 Placental parasitaemia: presence of malaria in the placental blood	2	722	Risk Ratio (M‐H, Random, 95% CI)	0.14 [0.05, 0.39]
4.1 Primigravidae and secundigravidae	2	517	Risk Ratio (M‐H, Random, 95% CI)	0.19 [0.06, 0.57]
4.2 Multigravidae (greater than 2 pregnancies)	1	205	Risk Ratio (M‐H, Random, 95% CI)	0.07 [0.02, 0.29]
5 Maternal peripheral parasitaemia	2	722	Risk Ratio (M‐H, Random, 95% CI)	0.11 [0.04, 0.33]
5.1 Primigravidae and secundigravidae	2	517	Risk Ratio (M‐H, Random, 95% CI)	0.16 [0.06, 0.40]
5.2 Multigravidae (greater than 2 pregnancies)	1	205	Risk Ratio (M‐H, Random, 95% CI)	0.04 [0.01, 0.29]