Comparison 3. Monthly sulfadoxine pyrimethamine (SP) compared to standard 2‐dose SP ‐ worst‐case scenario.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Maternal anaemia: haemoglobin less than 11g/dl.	2	722	Risk Ratio (M‐H, Random, 95% CI)	1.32 [1.05, 1.66]
1.1 Primigravidae and secundigravidae	2	517	Risk Ratio (M‐H, Random, 95% CI)	1.20 [1.01, 1.42]
1.2 Multigravidae (greater than 2 pregnancies)	1	205	Risk Ratio (M‐H, Random, 95% CI)	1.66 [1.21, 2.27]
2 Low Birth Weight: birth weight less than 2.5 kg	2	722	Risk Ratio (M‐H, Random, 95% CI)	1.91 [0.85, 4.28]
2.1 Primigravidae and secundigravidae	2	517	Risk Ratio (M‐H, Random, 95% CI)	1.25 [0.86, 1.82]
2.2 Multigravidae	1	205	Risk Ratio (M‐H, Random, 95% CI)	5.03 [2.35, 10.76]
3 Neonatal mortality	2	722	Risk Ratio (M‐H, Random, 95% CI)	2.21 [0.05, 100.84]
3.1 Primigravidae and secundigravidae	1	266	Risk Ratio (M‐H, Random, 95% CI)	0.32 [0.09, 1.17]
3.2 Primigravidae, secundigravidae and multigravidae women	1	456	Risk Ratio (M‐H, Random, 95% CI)	14.85 [4.67, 47.16]
4 Placental parasitaemia: presence of malaria in the placental blood	2	722	Risk Ratio (M‐H, Random, 95% CI)	3.24 [0.35, 30.02]
4.1 Primigravidae and secundigravidae	2	517	Risk Ratio (M‐H, Random, 95% CI)	1.39 [0.13, 14.40]
4.2 Multigravidae (greater than 2 pregnancies)	1	205	Risk Ratio (M‐H, Random, 95% CI)	26.67 [3.70, 192.32]
5 Maternal peripheral parasitaemia	2	722	Risk Ratio (M‐H, Random, 95% CI)	2.22 [0.25, 20.15]
5.1 Primigravidae and secundigravidae	2	517	Risk Ratio (M‐H, Random, 95% CI)	0.88 [0.09, 8.57]
5.2 Multigravidae (greater than 2 pregnancies)	1	205	Risk Ratio (M‐H, Random, 95% CI)	22.86 [3.15, 165.80]