Filler 2006.

Methods	Design: RCT
Participants	Number: 266 were enrolled Inclusion Criteria: HIV positive women in the first or second pregnancy Exclusion criteria: prior adverse reaction to sulfa‐containing drugs
Interventions	1. Monthly intermittent preventive treatment using sulphadoxine‐pyrimethamine 2. Control: 2 doses of sulphadoxine‐pyrimethamine
Outcomes	1. Maternal anaemia 2. Peripheral parasitaemia 3. Placental parasitaemia 4. Maternal haemoglobin at delivery 5. Neonatal death 6. Birth weight 7. ADR Not included in this review Uncomplicated malaria 3rd trimester anaemia
Notes	Location: Malawi Date: 2002‐5 Funding: WHO/ CDC
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Generation of allocation sequence: permuted blocks of random length.
Allocation concealment (selection bias)	Unclear risk	No details of allocation concealment are given by the study.
Blinding (performance bias and detection bias) Clinicians	High risk	No. "Neither study participants nor clinicians were blinded to group assignment".
Blinding (performance bias and detection bias) Patients	High risk	No. "Neither study participants nor clinicians were blinded to group assignment".
Blinding (performance bias and detection bias) Technicians	Low risk	Blinding was only done for the laboratory technicians assessing the outcome of placental malaria
Incomplete outcome data (attrition bias) All outcomes	High risk	The proportion of missing outcomes compared with observed event risk enough to induce clinically relevant bias in intervention effect estimate as demonstrated by the sensitivity analysis .
Selective reporting (reporting bias)	Unclear risk	The method section does not set out clearly the outcomes which were to be measured.
Other bias	Low risk	No other biases suspected.