Hamer 2007.

Methods	Design: RCT
Participants	Number: 456 were enrolled Inclusion Criteria: HIV positive women of any gravidity Exclusion criteria: prior adverse reaction to sulfa‐containing drugs and women aged <18 years
Interventions	1. Monthly intermittent preventive treatment using sulphadoxine‐pyrimethamine 2. Control: 2 doses of sulphadoxine‐pyrimethamine, one in 2nd trimester and the other in 3rd trimester
Outcomes	1. Placental malaria (by histology) 2. Placental parasitaemia 3. Peripheral parasitaemia 4. Placental malaria 5. Maternal anaemia at delivery 6. LBW 7. ADR Not included in this review 1. Gestational age 2. Uncomplicated malaria 3. Cord blood parasitaemia
Notes	Location: Zambia Date: 2003 ‐ 4 Funding: Cooperative Agreement No. S1954‐21/21
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Generation of allocation sequence: randomization was done in blocks of 20
Allocation concealment (selection bias)	Low risk	Allocation concealment: participants were assigned sequential ID numbers corresponding to a sealed package of trial drugs whilst randomization codes were retained in the USA
Blinding (performance bias and detection bias) Clinicians	Low risk	Investigators were blinded.
Blinding (performance bias and detection bias) Patients	Low risk	Trial participants were blinded.
Blinding (performance bias and detection bias) Technicians	Low risk	Laboratory/ pathologists were all blinded
Incomplete outcome data (attrition bias) All outcomes	High risk	Inclusion of randomized participants in the analysis: participants with data available were analyzed and not everyone randomised
Selective reporting (reporting bias)	Low risk	All outcomes are included in the results section.
Other bias	Low risk	No other biases suspected.

RCT = Randomized Controlled Trial
 HIV = Human Immonodeficiency Virus
 ADR = Adverse Drug Reactions
 CDC = Centers for Disease Control
 WHO = World Health Organization
 LBW = Low Birth Weight