Study	Reason for exclusion
Baumhackl 2003	Small cohort study carried out on 30 participants with confirmed diagnosis of multiple sclerosis
Craig 1999	Cohort study to state an accelerated immunization schedule for military personnel or travellers
Dengler 1999	Study carried out in heart transplanted recipients with the aim to evaluate vaccine efficacy in a risk population
Hedenstrom 1995	Randomized study comparing the effect on immunogenicity and adverse events of TBE vaccine alone or TBE vaccine plus immunoglobulin in 128 adults; no unvaccinated or placebo groups
Leonova 2007	Study in which antibody response to Encepur vaccine was determined; no control group
Mamoli 1981	Randomized study comparing the effect of TBE vaccine and placebo on electroencephalogram (EEG) as a marker of a post‐vaccine reaction
Panasiuk 2003	Small non‐randomized study (8 women, 21 men) carried out in HIV‐infected people to investigate immunogenicity and safety of the vaccine against TBE
Rosenkranz 1997	Not original data; definition of equivalence criterion on data from Girgsdies 1996
Schöndorf 2006	No control group; effect of booster dose administration in participants who were already immunized with rapid schedule at least 2 years before
Vene 2007	Not comparative design; serological comparison of 3 groups of participants with different immunization history
Zent 2003	Multicentre study with no control group to investigate immune response after booster immunization with new TBE vaccine for adults (Encepur)
Zoulek 1986	Small study (20 participants) comparing immune response following intradermal or intramuscular administration of FSME‐IMMUN to young adults in Germany; no randomization mentioned

HIV: human immunodeficiency virus; TBE: tick‐borne encephalitis.