Bock 1990.

Methods	Design: randomized controlled trial Generation of allocation sequence: not described Allocation concealment: not described Blinding: single blind Inclusion of all randomized participants in the analysis: none lost to follow up Length of follow up: 56 days
Participants	Number: 56 healthy male aged 20 to 50 years Inclusion criteria: not reported Exclusion criteria: not reported
Interventions	Vaccine: Encepur Dose‐finding study: 1. 0.03 μg, 6 participants 2. 0.18 μg, 5 participants 3. 0.35 μg, 18 participants 4. 1.00 μg, 16 participants 5. 3.00 μg, 11 participants Schedule: 2 inoculations on days 0 and 28 at 5 different dosages in 0.5 mL
Outcomes	1. Geometric means of tick‐borne encephalitis (TBE) antibody titres 28 days after second inoculation (as assayed by enzyme‐linked immunosorbent assay (ELISA), haemagglutination inhibition test, and neutralization test): minimum, median, and maximum values 2. Reactogenicity assessed by medical check‐up on vaccination day, 2 days later and for a follow‐up period of 28 days after each injection: local and systemic "Adverse Drug Events" (ADEs)
Notes	Location: Germany