Comparison 1. Sulfadoxine‐pyrimethamine (SP) plus artesunate (AS) versus SP plus amodiaquine (AQ).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Treatment failure by day 28	3	652	Risk Ratio (M‐H, Fixed, 95% CI)	0.59 [0.42, 0.83]
2 Treatment failure by day 28 (excludes new infections)	3	649	Risk Ratio (M‐H, Fixed, 95% CI)	0.62 [0.40, 0.96]
3 Treatment failure by day 14	4	775	Risk Ratio (M‐H, Fixed, 95% CI)	1.14 [0.47, 2.78]
4 Treatment failure: progress to severe malaria	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
5 Gametocyte carriage at day 7	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
6 Gametocyte carriage at day 14	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected