Amerio 2003.

Methods	Design: randomized controlled trial Generation of allocation sequence: computer generated Allocation concealment: phone call‐based procedure Blinding: investigators only Inclusion of randomized participants in the analysis: 100%
Participants	Number: 40 enrolled (mean age 44, standard deviation 17; 19 males, 21 females) Inclusion criteria: immunocompetent; aged 18 to 75; microscopically confirmed uncomplicated scabies Exclusion criteria: HIV positive; severe renal failure; liver insufficiency; acute or chronic leukaemia; lymphoma; use of antiscabietic preparations in previous 30 days; pregnancy; breastfeeding
Interventions	1. 5% permethrin cream (20 participants) 2. 0.16% natural pyrethrins synergized with pyperonil butoxide (1.65%) in thermolabile foam ("Milice", Mipharm, Italy) (20 participants) Both medications applied to entire body surface except head for 8 h overnight on 2 consecutive days, and then same treatment repeated after 14 days
Outcomes	1. Number of participants with clearance of lesions at 4 weeks 2. Number of participants with complete relief of itching at 4 weeks Not included in this review: 3. Number of participants with clearance of lesions at 2 weeks 4. Number of participants with complete relief of itching at 2 weeks 5. Clinical grading score (semi‐quantitative measure of numbers of lesions) at 2 and 4 weeks 6. Itching score at 2 and 4 weeks 7. Numbers of days taking antihistamine drugs 8. Numbers of participants with secondary skin infection
Notes	Location: Italy Date: March 2001 to October 2001 Trial supported by unrestricted grant from Mipharm SpA