Taplin 1990.

Methods	Design: randomized controlled trial Generation of allocation sequence: unclear Allocation concealment: "medications supplied in identical ... tubes that were coded and randomized" Blinding: investigators Inclusion of randomized participants in the analysis: 98% (2/96 participants lost to follow up)
Participants	Number: 96 enrolled (aged 2 months to 5 years; 42 males, 54 females) Inclusion criteria: clinical diagnosis and the recovery of at least 1 live mite Exclusion criteria: none stated
Interventions	1. 10% crotamiton cream (48 participants) 2. 5% permethrin cream (48 participants) Both medications applied as single application from head to toe and left for 8 to 10 h
Outcomes	1. Number of participants with no new lesions and all original active lesions healed at 28 days 2. Number of participants with persistence of pruritus at 28 days 3. Adverse events Not included in this review: 4. Number of participants with no new lesions and all original active lesions healed at 14 days 5. Number of participants with persistence of pruritus at 14 days
Notes	Location: Panama Date: 1985 Household contacts were treated with 5% permethrin cream 65/96 (68%) participants had secondary cutaneous infection Study supported in part by a grant from Burroughs Wellcome (manufacturers of permethrin)