Skip to main content
. 2007 Jul 18;2007(3):CD000320. doi: 10.1002/14651858.CD000320.pub2

Zargari 2006.

Methods Design: randomized controlled trial
Generation of allocation sequence: unclear
Allocation concealment: "drugs ... packaged in identical appearing tubes and randomized and coded by the manufacturer"
Blinding: participants and investigators
Inclusion of randomized participants in the analysis: 84.6% (18/117 lost to follow up)
Participants Number: 117 enrolled (aged 6 to 64 years, mean age 30.2 years +/‐ 15.3; 55 males and 44 females followed up)
Inclusion criteria: clinically diagnosed scabies (defined as burrow or typical lesions at classical sites plus nocturnal pruritus plus similar symptoms in contacts) and/or microscopically diagnosed scabies (demonstration of egg, larvae, mite, or faecal material)
Exclusion criteria: < 5 years of age; treatment with antiscabietic medication or topical steroid in previous 4 weeks; pregnancy; breastfeeding; severe central nervous system, hepatic, or renal problems
Interventions 1. 5% permethrin cream (59 participants)
 2. 1% lindane cream (58 participants)
Both medications applied as a single application head to toe, and repeated 1 week later
Outcomes 1. Number of participants with no new lesions and improvement in itching at 14 days
 2. Adverse events
Notes Location: Iran
Date: December 2002 to October 2003
Treatment advised for all family members and close contacts
Study supported by Gilaranco Company (manufacturers of permethrin and lindane)