Date	Event	Description
17 August 2006	New citation required and conclusions have changed	2006, Issue 4 (substantive update): The conclusions of the review have changed due to inclusion of information obtained from the new trials that have been carried out since it was first published. We have subjected the results of the included trials to meta‐analysis. The search for trials has been updated.
11 August 2006	New search has been performed	2006, Issue 4 (substantive update): The conclusions of the review have changed due to inclusion of information obtained from the new trials that have been carried out since it was first published. We have subjected the results of the included trials to meta‐analysis. The search for trials has been updated.
8 May 2003	Amended	2003, Issue 3 (first review version): The order of the outcome measures has changed from those in the protocol. This is because our primary interest is how the clinical manifestations of the disease are affected by malaria chemoprophylaxis. Sickle cell painful crises and severe anaemia have been moved from secondary to primary outcome measures; and episodes of malaria has been moved to secondary outcome measures where it has been renamed malaria infection. We have also clarified in the secondary outcome measures that the steady state in which haemoglobin concentrations are measured is that in which symptoms attributable to sickle cell disease or infection are absent.