Eke 2003.

Methods	Randomized controlled trial Generation of allocation sequence: block randomization (1 in 6); equal allocation Allocation concealment: participants selected their intervention groups from sealed opaque envelopes Blinding: none Inclusion of all randomized participants in analysis: > 90% participants followed up for 9 months (32/35 proguanil group, 29/30 placebo group, and 100% pyrimethamine group)
Participants	97 children with homozygous sickle cell disease (sickle cell anaemia genotype SS)
Interventions	1. Pyrimethamine (0.5 mg/kg/week) 2. Proguanil (1.5 mg/kg/day) 3. Placebo (vitamin C; 1 mg/kg/day for 9 months)
Outcomes	1. Deaths 2. Malaria infections 3. Bone pain crises 4. Haemolytic crises 5. Aplastic crisis 6. Number of hospitalizations 7. Number of blood transfusions 8. Mean haemoglobin levels 9. Mean parasite density 10. Splenomegaly
Notes	Location: University of Port Harcourt Teaching Hospital, Nigeria