Warley 1965.

Methods	Quasi‐randomized controlled trial Generation of allocation sequence: alternate allocation Allocation concealment: none Blinding: none Inclusion of all randomized participants in analysis: < 30% of participants followed up for 12 months (13/60 intervention group and 19/66 control group)
Participants	126 children with homozygous sickle cell disease (sickle cell anaemia genotype SS)
Interventions	1. Chloroquine tablet (100 mg < 3 years; 200 mg > 3 years) plus benzathine penicillin injection (1,200,000 units) 2. No tablets plus sterile water injection
Outcomes	1. Parasitaemia 2. Dactylitis 3. Mean haemoglobin 4. Fall in haemoglobin
Notes	Location: Mulago Hospital, Uganda Date: August 1962 to May 1964