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. 1999 Oct 25;1999(4):CD001362. doi: 10.1002/14651858.CD001362

Hong Kong 1979a.

Methods Randomized trial of 2‐, 3‐, and 12‐month regimens, with shorter regimens containing 4 drugs.
Participants 1212 adults with sputum smear negative, radiographically active TB.
691 culture negative, 381 culture positive, analyzed separately.
Excluded from relapse analysis:
Pretreatment ineligiblity: 9/1212 (1%)
 Side effects: 32/691 (5%) (culture negative patients only)
 Other reasons: 91/691 (13%) (culture negative patients only)
Interventions 2SHRZ
 3SHRZ
 3SPH/9SHI
Daily dosages:
 S: 0.75 g
 H: 300 mg
 R: 450 mg
 Z: 1.5 g (<50 kg), 2.0 (>50 kg)
 PAS: 10 g
Intermittent (2X/week):
 S: 1.0 g
 H: 15 mg/kg
Outcomes Bacteriologic relapse 12 months after starting treatment.
Notes Follow‐up period is shorter than other studies.