Comparison 2.
Alternating versus single agent
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
|---|---|---|---|---|
| 1 Non‐communicating Children's Pain Checklist (NCCPC) score | 1 | 1857 | Mean Difference (IV, Random, 95% CI) | ‐3.24 [‐3.82, ‐2.67] |
| 1.1 Day 1 | 1 | 619 | Mean Difference (IV, Random, 95% CI) | ‐2.36 [‐2.76, ‐1.96] |
| 1.2 Day 2 | 1 | 619 | Mean Difference (IV, Random, 95% CI) | ‐3.76 [‐4.18, ‐3.34] |
| 1.3 Day 3 | 1 | 619 | Mean Difference (IV, Random, 95% CI) | ‐3.64 [‐4.08, ‐3.20] |
| 2 Absent from daycare, days | 1 | 619 | Mean Difference (IV, Fixed, 95% CI) | ‐0.85 [‐0.95, ‐0.75] |
| 3 Doses of medication per child | 1 | 2166 | Mean Difference (IV, Random, 95% CI) | ‐1.29 [‐1.69, ‐0.88] |
| 3.1 Day 1 | 1 | 619 | Mean Difference (IV, Random, 95% CI) | ‐1.09 [‐2.40, 0.22] |
| 3.2 Day 2 | 1 | 619 | Mean Difference (IV, Random, 95% CI) | ‐1.39 [‐2.29, ‐0.49] |
| 3.3 Day 3 | 1 | 928 | Mean Difference (IV, Random, 95% CI) | ‐1.39 [‐1.48, ‐1.30] |
| 4 Mean temperature (°C) | 2 | Mean Difference (IV, Random, 95% CI) | Subtotals only | |
| 4.1 Hour 1 | 1 | 40 | Mean Difference (IV, Random, 95% CI) | 0.0 [‐0.28, 0.28] |
| 4.2 Hour 4 | 2 | 78 | Mean Difference (IV, Random, 95% CI) | ‐0.60 [‐0.94, ‐0.26] |
| 4.3 Hour 6 | 1 | 40 | Mean Difference (IV, Random, 95% CI) | ‐1.60 [‐2.27, ‐0.93] |
| 5 Proportion remaining febrile | 2 | Risk Ratio (M‐H, Fixed, 95% CI) | Subtotals only | |
| 5.1 Hour 1 | 1 | 40 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.0 [0.29, 3.45] |
| 5.2 Hour 4 | 1 | 40 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.08 [0.00, 1.28] |
| 5.3 Hour 6 | 2 | 109 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.25 [0.11, 0.55] |