Comparison 3.

Combined versus alternating therapy

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Temperature (°C)	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
1.1 Hour 1	1	40	Mean Difference (IV, Fixed, 95% CI)	‐0.20 [‐0.48, 0.08]
1.2 Hour 4	1	40	Mean Difference (IV, Fixed, 95% CI)	0.0 [‐0.19, 0.19]
1.3 Hour 6	1	40	Mean Difference (IV, Fixed, 95% CI)	0.30 [0.01, 0.59]
2 Proportion Febrile	1	120	Risk Ratio (M‐H, Fixed, 95% CI)	0.78 [0.21, 2.91]
2.1 Hour 1	1	40	Risk Ratio (M‐H, Fixed, 95% CI)	0.5 [0.10, 2.43]
2.2 Hour 4	1	40	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
2.3 Hour 6	1	40	Risk Ratio (M‐H, Fixed, 95% CI)	3.0 [0.13, 69.52]