Table 1.

Dosing regimens and timing

Study ID	Time after administration (hours)
	0	1	2	3	4	5	6	7	8
Erlewyn‐Lajeunesse 2006	P (15 mg/kg)	Ⓣ	Ⓣ
	I (5 mg/kg)	Ⓣ	Ⓣ
	P (15 mg/kg) + I (5 mg/kg)	Ⓣ	Ⓣ
Hay 2008	P (15 mg/kg)		Ⓣ		Ⓣ P		Ⓣ		Ⓣ
	I (10 mg/kg)		Ⓣ		Ⓣ		Ⓣ I		Ⓣ
	P (15 mg/kg) + I (10 mg/kg)		Ⓣ		Ⓣ P		Ⓣ I		Ⓣ
Kramer 2008	P (15 mg/kg)			Ⓣ	Ⓣ P	Ⓣ	Ⓣ
	P (15 mg/kg)			Ⓣ I (10 mg/kg)	Ⓣ	Ⓣ	Ⓣ
Nabulsi 2006	I (10 mg/kg)				Ⓣ	Ⓣ	Ⓣ	Ⓣ	Ⓣ
	I (10 mg/kg)				Ⓣ P (15 mg/kg)	Ⓣ	Ⓣ	Ⓣ	Ⓣ
Paul 2010	I (10 mg/kg)	Ⓣ	Ⓣ	Ⓣ	Ⓣ	Ⓣ	Ⓣ
	I (10 mg/kg)	Ⓣ	Ⓣ	Ⓣ P	Ⓣ	Ⓣ	Ⓣ
	I (10 mg/kg) + P (15 mg/kg)	Ⓣ	Ⓣ	Ⓣ	Ⓣ	Ⓣ	Ⓣ
Sarrell 20061	P or I						P
	P or I								I
	P or I				P				I

Ⓣ = Temperature reported; P = paracetamol; I = ibuprofen

¹Sarrell 2006 asked caretakers to record rectal temperatures three times per day.