Comparison 1. Combined versus single agent.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Mean temperature (°C)	3		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
1.1 Hour 1	2	163	Mean Difference (IV, Fixed, 95% CI)	‐0.27 [‐0.45, ‐0.08]
1.2 Hour 4	2	173	Mean Difference (IV, Fixed, 95% CI)	‐0.70 [‐1.05, ‐0.35]
1.3 Hour 6	1	40	Mean Difference (IV, Fixed, 95% CI)	‐1.30 [‐2.01, ‐0.59]
2 Proportion remaining febrile	2		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
2.1 Hour 1	1	40	Risk Ratio (M‐H, Random, 95% CI)	0.5 [0.10, 2.43]
2.2 Hour 4	2	196	Risk Ratio (M‐H, Random, 95% CI)	0.08 [0.02, 0.42]
2.3 Hour 6	1	40	Risk Ratio (M‐H, Random, 95% CI)	0.10 [0.01, 0.71]