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| Methods | Randomization by ward or building. | |
| Participants | 24,838 patients in 37 county institutions for chronic psychiatric or mentally retarded in Wisconsin, Georgia, and Massachusetts, U.S.A. PPD >5mm in 50%. Age 2‐100, >85% white, mean age 48 (men) 54 (women). |
|
| Interventions | Isoniazid 300 mg daily for 12 months. | |
| Outcomes | 1. Active tuberculosis 2. Death | |
| Notes | 91% had normal chest x‐ray, 9% abnormal at baseline. | |
