Escobar 1988.

Methods	Randomization: no details Allocation concealment: no details Blinding: double (vaccine and placebo were identical) Data collection: no details Intention to treat: no information Interim analysis: no information Exclusion from analysis: no information Follow‐up period: 3 weeks after vaccination
Participants	Age: 6 to 18 months Health status: without diarrhoea, no further details Breastfeeding: no information Immunization status: no information
Interventions	1. Bovine RIT 4237, 0.5 ml, 10^8 DICT 50, single dose (n = 52) 2. Placebo (same preparation without the virus), single dose (n = 51) 110 ml of formula given before vaccine or placebo
Outcomes	1. Efficacy: rotavirus diarrhoea within 3 weeks of vaccination
Notes	Study location: Spain Clinical symptoms: clinical evaluation, no further details Laboratory studies: serology and stool analysis by ELISA