Kochar 1997.
Methods | Block randomization based on days of admission Inadequate concealment of allocation, no blinding Losses to follow up/post‐randomization exclusion not stated |
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Participants | Age: 14 to 74 years Intervention group: 102 Control group: 83 Inclusion criteria: Plasmodium falciparum in peripheral blood smear; coma for at least half an hour (Glasgow coma score ≥ 6); no generalized seizure in previous 2 hours; exclusion of other causes of fever with altered consciousness Exclusion criteria: diabetes; space‐occupying lesion; psychiatric illness; alcoholism; head injury; chronic renal failure |
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Interventions | Intervention: injection phenobarbitone 10 mg/kg body weight (not more than 400 mg) Control: nothing given |
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Outcomes | 1. Death 2. Seizure | |
Notes | Study location: malaria epidemics in Bikaner, Rajastan, India |