Skip to main content
. 2002 Apr 22;2002(2):CD002152. doi: 10.1002/14651858.CD002152

White 1988.

Methods Randomized
Placebo controlled parallel trial
Treatment concealed in sealed envelopes
Losses to follow up/post‐randomization exclusion not stated
Participants Number screened not given
Number included: 24 intervention; 24 placebo; 40 male; 8 female
Inclusion criteria: cerebral malaria (unrousable coma in falciparum malaria)
Exclusion criteria: other causes of coma
Interventions Intervention: intramuscular phenobarbitone (Gardenal Sodium: May & Baker); single dose of 200mg (1 ml ampoule) for participants > 60 kg weight; 3.5 mg/kg (or 0.0175 ml/kg) for < 60 kg weight
Placebo: saline in identical ampoule (same dose in 'ml' as intervention)
Outcomes 1. Death
 2. Seizure
 3. Coma recovery time
Notes Setting: Chantaburi and Kanchanaburi, Thailand