White 1988.
Methods | Randomized Placebo controlled parallel trial Treatment concealed in sealed envelopes Losses to follow up/post‐randomization exclusion not stated |
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Participants | Number screened not given Number included: 24 intervention; 24 placebo; 40 male; 8 female Inclusion criteria: cerebral malaria (unrousable coma in falciparum malaria) Exclusion criteria: other causes of coma |
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Interventions | Intervention: intramuscular phenobarbitone (Gardenal Sodium: May & Baker); single dose of 200mg (1 ml ampoule) for participants > 60 kg weight; 3.5 mg/kg (or 0.0175 ml/kg) for < 60 kg weight Placebo: saline in identical ampoule (same dose in 'ml' as intervention) |
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Outcomes | 1. Death 2. Seizure 3. Coma recovery time | |
Notes | Setting: Chantaburi and Kanchanaburi, Thailand |