Table 1.
Stimuli used to induce sensitization of the hypertensive response
| Stressor | Route of administration | Duration of challenge | Ref. |
|---|---|---|---|
| Systemic stressors | |||
| Non-pressor ANG II | Subcutaneous | 1 week | 1 |
| Non-pressor ANG II | Intracerebroventricular | 1 week | 1 |
| Non-pressor aldosterone | Subcutaneous | 1 week | 2 |
| Non-pressor aldosterone | Intracerebroventricular | 1 week | 2 |
| High-sodium diet | Food | 2 weeks | 116 |
| High-fat diet | Food | 3 weeks | 131 |
| Low-sodium diet | Food | 2 weeks | 116 |
| Hypotensive haemorrhage | NA | 3 times in 1 week | 248 |
| Lipopolysaccharide | Intraperitoneal | 3 times in 1 week | Unpublished |
| Leptin | Intracerebroventricular | 1 week | 134 |
| TNFα | Intracerebroventricular | 1 week | 131 |
| Processive stressor | |||
| Resident-intruder social defeat | External and/or psychosocial | 3 times in 1 week | 132, 133 |
| Perinatal challenge to offspring | |||
| Maternal gestational hypertension | ANG-elicited hypertension | 3 weeks of pregnancy | 191 |
| Maternal high-fat diet | Food | 3 weeks of pregnancy | 135 |
| Maternal high-fat diet | Food | 3 weeks of lactation | 135 |
| Maternal high-fat diet | Food | 3 weeks of pregnancy plus 3 weeks of lactation | 135 |
Expression of sensitization of the hypertensive response was tested by subcutaneous administration of angiotensin II 120 ng/kg/min. ANG, angiotensin; NA, not applicable; TNF, tumour necrosis factor-α.