Table 1.
Clinical characteristics of TOLSURF participants included in genetic studies of corticosteroid response by maternal self-reported race/ethnicity
| African-American (N=34) |
Non-Hispanic White (n=36) |
|
|---|---|---|
| Demographics | ||
| Gestational age (weeks) | 24.7 ± 1.0 | 25.6 ± 1.3 |
| Birth weight (g) | 667 ± 119 | 742 ± 169 |
| Birth weight centile | 42 ± 25 | 43 ± 31 |
| Antenatal corticosteroid exposure | 30 (78.9) | 34 (87.2) |
| Cesarean delivery | 23 (60.5) | 29 (74.4) |
| Male sex | 19 (50.0) | 27 (69.2) |
| Product of multiple gestation | 8 (21.1) | 10 (25.6) |
| RSS and STEROID Variables | ||
| Postnatal age at start of steroid treatment (days) | 29.2 ± 15.8 | 22.8 ± 9.09 |
| Dexamethasone (N, %) | 18 (47) | 13 (33) |
| RSS at TOLSURF Study Entry | 4.54 ± 2.52 | 4.66 ± 2.36 |
| RSS at Day 0 | 6.85 ± 2.51 | 7.08 ± 3.12 |
| RSS at Day 4 | 4.45 ± 2.74 | 4.97 ± 2.73 |
| RSS at Day 7 | 3.69 ± 1.62 | 4.14 ± 2.80 |
| BPD Diagnosis at 36 weeks* N (%) | 26 (76.5) | 32 (82.1) |
| BPD Diagnosis at 40 weeks* N (%) | 16 (47.1) | 23 (58.9) |
RSS: Respiratory Severity Score, BPD: Bronchopulmonary Dysplasia
Among living infants, 4 of 38 AAs died before 36 weeks with no further deaths before 40 weeks. There were no deaths among the 39 NHW infants.