. Author manuscript; available in PMC: 2019 May 23.

Published in final edited form as: Pediatr Res. 2018 Nov 22;85(5):625–633. doi: 10.1038/s41390-018-0235-1

Table 2. Candidate SNP Association Testing for absolute change in Respiratory Severity Score (RSS) at Day 7.

Linear regression was used to test for an association between copies of the A1 allele and respiratory outcome. Imputed genetic variants have a corresponding quality score (Rsq), otherwise “NA” if the variant was genotyped directly.

			African-Americans (N=34)				Non-Hispanic Whites (N=36)					All, n=87
Gene	SNP	A1/A2	FreqA1	Difference in absolute change in RSS with 1 variant allele	SE	P	FreqA1	Difference in absolute change in RSS with 1 variant allele	SE	P	Meta-P	Merged-P	Rsq
Perinatal Steroids and Respiratory Outcomes – Candidate Genes and SNPs
CRH	rs4613981	A/G	0.27	0.15	0.56	0.79	0.85	1.01	0.83	0.23	0.18	0.091	0.98
CRH	rs2446432	C/A	0.33	0.55	0.45	0.23	0.53	0.97	0.80	0.23	0.055	0.027	NA
SERPINA6	rs3748320	A/G	0.06	0.26	1.01	0.80	0.28	1.40	0.74	0.068	0.054	0.041	0.99
CRHR1	rs7225082	T/G	0.36	1.19	0.46	0.017	0.64	1.74	0.68	0.016	*2.8×10⁻⁴*	1.5×10⁻³	0.89
CRHR1	rs173365	G/A	0.33	0.15	0.46	0.74	0.50	0.48	0.54	0.38	0.28	0.32	0.95
Steroid Treatment of Asthma – Candidate Genes and SNPs
ALLC	rs11123610	A/G	0.53	0.54	0.42	0.21	0.63	0.35	0.58	0.55	0.12	0.19	0.88
T	rs6456042	A/C	0.44	0.32	0.39	0.42	0.46	0.28	0.63	0.66	0.27	0.35	0.97
T	rs3127412	C/T	0.44	0.32	0.39	0.42	0.46	0.28	0.63	0.66	0.27	0.35	0.98
GLCCI1	rs37972	T/C	0.17	0.52	0.58	0.38	0.38	−0.06	0.59	0.92	0.35	0.60	0.91
CYP3A4	rs35599367	A/G	0.02	0.30	1.97	0.88	0.03	−0.12	2.00	0.95	0.84	0.93	0.84
STIP1	rs4980524	C/A	0.31	−0.50	0.60	0.41	0.43	0.12	0.60	0.84	0.34	0.91	0.99
STIP1	rs6591838	G/A	0.22	−0.65	0.68	0.35	0.25	1.15	0.62	0.08	0.026	0.24	0.98
STIP1	rs2236647	C/T	0.38	0.41	0.47	0.39	0.56	−0.07	0.58	0.91	0.36	0.92	0.98
CRHR1	rs242941	C/A	0.30	0.73	0.47	0.14	0.63	1.24	0.59	0.04	5.9×10⁻³	0.010	NA
CRHR1	rs1876828	T/C	0.08	0.50	0.90	0.58	0.24	0.34	0.69	0.62	0.36	0.48	0.99
TBX21	rs4794067	C/T	0.17	0.92	0.53	0.09	0.32	0.67	0.70	0.35	0.033	0.068	NA
TBX21	rs11650451	A/G	0.05	2.81	0.92	5.5×10⁻³	0.17	0.54	0.85	0.53	2.9×10⁻³	0.16	NA
TBX21	rs2240017	G/C	0.00	NA	NA	NA	0.01	−3.08	2.69	0.26	NA	0.14	0.57
TBX21	rs1134481	T/G	0.27	−0.12	0.62	0.85	0.47	0.22	0.64	0.74	0.63	0.62	0.96
TBX21	rs2305089	T/C	0.27	0.53	0.49	0.29	0.43	0.51	0.66	0.45	0.13	0.42	0.94
TBX21	rs3099266	T/C	0.23	0.37	0.53	0.50	0.47	0.11	0.70	0.88	0.43	0.46	0.95

FreqA1 = frequency of the A1 allele; SE = standard error; P=p-value; Rsq = imputation quality score