Table 3. Gene-Based Association Testing for absolute change in Respiratory Severity Score (RSS) at Day 7.
P-values were combined across all genotyped SNPs within 50 kb of candidate genes using VEGAS2. No individual gene surpassed Bonferroni adjustment for 18 comparisons (9 genes × 2 populations, 0.05/18=0.0028), and no individual SNP within a gene surpassed Bonferroni adjustment for the total number of SNPs within each gene (N SNPs).
| African-Americans (N=34) | Non-Hispanic Whites (N=36) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Gene | N SNPs | Test
statistic |
p-value | Top SNP | Top SNP
p- value |
N SNPs | Test
statistic |
p-value | Top SNP | Top SNP
p-value |
| Perinatal Steroids and Respiratory Outcomes | ||||||||||
| CRH | 33 | 30.8 | 0.457 | rs7841890 | 0.028 | 28 | 36.65 | 0.21 | rs7835948 | 0.082 |
| CRHR1 | 15 | 13.3 | 0.495 | rs114764500 | 0.067 | 10 | 10.69 | 0.36 | rs242941 | 0.060 |
| SERPINA6 | 56 | 46.5 | 0.616 | rs56170999 | 0.002 | 44 | 87.70 | 0.03 | rs3827896 | 0.0012 |
| Steroid Treatment of Asthma – Candidate Genes | ||||||||||
| ALLC | 47 | 46.4 | 0.435 | rs1367275 | 0.003 | 53 | 74.48 | 0.13 | rs1367276 | 0.008 |
| CYP3A4 | 28 | 34.0 | 0.297 | rs76994069 | 0.025 | 8 | 2.85 | 0.77 | rs78676479 | 0.277 |
| GLCCI1 | 58 | 69.8 | 0.220 | rs17143586 | 0.002 | 76 | 45.47 | 0.95 | rs10268598 | 0.088 |
| SERPINE1 | 46 | 52.5 | 0.288 | rs73712100 | 0.032 | 35 | 38.12 | 0.34 | rs10953321 | 0.013 |
| STIP1 | 16 | 10.7 | 0.699 | rs2701527 | 0.113 | 14 | 16.47 | 0.30 | rs118154228 | 0.085 |
| T | 31 | 63.5 | 0.020 | rs6456056 | 0.009 | 35 | 30.80 | 0.53 | rs10428822 | 0.024 |