Figure 7.

Multimodal longitudinal imaging of chronic choroidal neovascularization (CNV) in patient 6. Images were obtained 19 months apart. A, Color fundus photograph. B, Fluorescein angiography image cropped to same area as the OCT angiography (OCTA) image. C, Optical coherence tomography angiography image of CNV at the initial visit, when the patient’s visual acuity was 20/30. D, Optical coherence tomography angiography image of CNV at the follow-up visit, when the patient’s visual acuity was 20/30. E, Variable interscan time analysis (VISTA) OCTA image of CNV at the initial visit. F, Variable interscan time analysis OCTA image of CNV at the follow-up visit. Solid lines correspond to the CNV boundary at the initial visit and dashed lines correspond to the CNV boundary at the follow-up visit. Note the expansion of the CNV vasculature between the initial visit and follow-up visit. Additionally, note that the expansion of vasculature is accompanied by an increase in high flow-speed characteristics (red in the VISTA OCTA images). G, H, Optical coherence tomography B-scans at the initial visit and follow-up visit, respectively. I, J, Three-dimensional model of CNV at (I) the initial visit and (J) the follow-up visit. Note the enlargement of the lesion from (I) to (J). Note that in (I) and (J), the voxels are anisotropic, with the axial dimension being stretched by a factor of 10 so as to visualize better the 3-dimensional structure of the lesion.