Table 2. Raltegravir (RAL Wilcoxon test results).
n = 14 Volunteers; all men; mean age 23.3 ± 1.52. Significance was calculated among absolute values. "p value of change" represents the significance between endpoints after Phase 1 and Phase 2. "p value PREs" represents significance between values in basal circumstances. No changes were significant.
| Parameters | CHOL | HDL | LDL | TAG | GLU | mtDNA | Crt | AST | ALT | BIL | PROTp |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
Mean
PRE Placebo |
155.29 ± 7.9 | 50.86 ± 2.5 | 85.79 ± 6.4 | 92.79 ± 14.5 | 87.43 ± 2.2 | 1.747 ± 0.15 | 0.98 ± 0.02 | 23.93 ± 1.2 | 25.07 ± 2.5 | 0.69 ± 0.1 | 74.71 ± 0.8 |
|
Mean
POST Placebo |
152.71 ± 7.6 | 50.93 ± 2.3 | 88.43 ± 6.8 | 66.64 ± 7.2 | 87.71 ± 1.4 | 1.917 ± 0.16 | 1.02 ± 0.03 | 23.93 ± 1.3 | 26.21 ± 3.4 | 0.76 ± 0.1 | 75.00 ± 0.6 |
|
Mean
PRE RAL |
152.57 ± 7.7 | 50.79 ± 2.6 | 79.71 ± 5.6 | 110.14 ± 22.3 | 87.79 ± 1.5 | 1.762 ± 0.17 | 1.00 ± 0.02 | 28.07 ± 3.4 | 28.07 ± 4.1 | 0.71 ± 0.1 | 73.29 ± 0.9 |
|
Mean
POST RAL |
154.36 ± 8.3 | 52.07 ± 2.5 | 88.86 ± 7.6 | 67.64 ± 7.2 | 85.07 ± 1.8 | 1.996 ± 0.17 | 1.02 ± 0.02 | 26.57 ± 2.9 | 25.71 ± 1.9 | 0.83 ± 0.1 | 75.43 ± 1.0 |
|
Change
Placebo (%) |
−1.66 ± 4.9 | 0.14 ± 4.5 | 3.08 ± 7.9 | −28.18 ± 7.8 | 0.33 ± 1.6 | 10.48 ± 8.9 | 2.74 ± 2.5 | 0.00 ± 5.2 | 4.56 ± 13.7 | 10.31 ± 10.2 | 0.38 ± 0.8 |
|
Change
RAL (%) |
1.17 ± 5.4 | 2.53 ± 4.9 | 11.47 ± 9.5 | −38.59 ± 6.5 | −3.09 ± 2.0 | 13.25 ± 9.5 | 2.15 ± 2.2 | −5.34 ± 10.4 | −8.40 ± 6.8 | 16.00 ± 13.9 | 2.92 ± 1.3 |
|
p value
change |
0.414 | 0.472 | 0.223 | 0.397 | 0.157 | 0.683 | 0.693 | 0.593 | 0.345 | 0.929 | 0.086 |
|
p value
PREs |
0.366 | 0.779 | 0.220 | 0.510 | 0.972 | 0.975 | 0.925 | 0.659 | 0.562 | 0.549 | 0.170 |
CHOL = Total cholesterol; HDL = High density lipoproteins; LDL = Low density lipoproteins; TAG = Triglycerides; GLU = Glucose; mtDNA = Mitochondrial DNA; Crt = Creatinine; AST = Aspartate aminotransferase; ALT = Alanine transferase; BIL = Bilirubin; PROTp = Total plasma proteins; PRE = Values before starting placebo/RAL; POST = Values after starting placebo/RAL.