Skip to main content
. 2019 May 23;14(5):e0217131. doi: 10.1371/journal.pone.0217131

Fig 5. SMI and PKM2 silencing induced apoptosis in NSCLC cell lines.

Fig 5

(A) Number of apoptotic nuclei by TUNEL assay were counted in 3 normal lung and 11 NSCLC cell lines after treating with 10–80μM of SMI or shRNA. Data are presented as mean ± SD from three independent experiments as described in Materials and Methods. (B) 1000 x magnification image of a NSCLC cell line to show apoptotic nuclei after treating with 10–80μM of SMI in TUNEL assay (C) SMI treatment induces Caspase 3/7 activity in normal lung and NSCLC cell lines in a concentration dependent manner. Data are presented as mean ± SD from three independent experiments as described in Materials and Methods.