Fig 1. High aspect ratio microdevices for the measurements of forces exerted by growing spheroids.

(A) Plane view of the circular arrangement of the PDMS pillars surrounding a spheroid. (B) Lateral view of the pillar displacement induced by a growing spheroid. (C) Forces (F) generated by the growing spheroid on the surrounding environment induce an outward displacement of the pillars. Pillars are defined by their diameter (d), height (h), and spring constant (K).