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. 2019 May 23;14(5):e0217216. doi: 10.1371/journal.pone.0217216

Fig 3. Increased CD3+ and CD4+ T-cell occurrence in the brainstem of SHR-72 transgenic rat model for tauopathies.

Fig 3

(A-D) Immunofluorescence staining showed CD4+ T-cells in SHR-72 transgenic animals. (E- H) Immunofluorescence staining showed more perivascular than brain parenchyma infiltrating CD4+ T-cells in SHR-72 transgenic animals. (I-L) Immunofluorescence staining showed CD3+ T-cells in SHR-72 transgenic animals. (M-P; white arrow) Immunofluorescence staining showed mainly intravascular CD3+ T-cells in SHR-72 transgenic animals. (R; white arrow) Presence of CD4+ extravascular and parenchymal T- cells, high magnification. (S) Presence of CD3+ intravascular T- cells, high magnification. (T) Quantification of intravascular, extravascular and parenchymal CD4+ and CD3+ T-cells. Scale bar 50 μm, (DAPI: blue color; pan- laminin: red color; CD4+marker: green, CD3+ marker: green), n = 7.