Fig 4. Rb^LoTem and Rb^HiTn transcriptomes reveal potential crosstalk mediators.

Rb^LoTem and Rb^HiTn cells were stimulated alone as before for 3 days, and RNA was isolated for deep sequencing and whole transcriptome analysis. Genes were arranged according to the log2 of the Rb^LoTem to Rb^HiTn ratio of expression, using the calculated RPKM values. Candidates were narrowed by excluding all membrane proteins, proteins known to exist only in the nucleus or cytoplasm, and those showing at least 16-fold increase in Rb^LoTem cells compared to Rb^HiTn cells. n = 2 per cell type.