Video 3. NL undocking and disruption of CNB in CNB+Latch mutant.

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DOI: 10.7554/eLife.44146.009

Representative simulation of CNB+Latch mutant motor domain in the ATP-bound state. The C-terminal half of the NL (N-latch residue N334 and β10) undocks from the core motor domain followed by disruption of the CNB. Secondary structure elements are colored as: coverstrand (CS, purple), α1 (dark green), β7 (yellow), Loop13 (L13, orange), β8 (teal), neck liker (NL: β9 and β10, light green), with α-tubulin (blue) and β-tubulin (light blue). The changes in residue-residue distances in the CNB+Latch mutant compared to the WT are listed in Supplementary file 3.