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Schematic diagram of the developed multiscale PBPK model for doxorubicin. (A) The whole-body PBPK model is comprised of 7 tissues and 2 blood compartments. Blood compartment are further divided into plasma and blood cell sub-compartments. (B) Tissue model. Each tissue is divided into vascular, interstitial, intracellular, and nucleus DNA bound sub-compartments.
