Fig 4.

Observed and predicted doxorubicin (Dox) concentration-time profiles in plasma and various tissues in humans. Observed data are shown as dots. Solid red lines depict the predicted median, dashed lines represent the predicted 5^th and 95^th percentiles, and the shaded areas depict the 5th−95th percentile population prediction intervals. Solid blue lines represent the predicted 5^th and 95^th percentiles of varied tumor blood flow (0.1 ~ 10 mL/min) and DNA concentrations (1.7 ~ 170 μmol/mL). (Supplemental materials reference 21–27)