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. Author manuscript; available in PMC: 2019 May 23.

Published in final edited form as: Pharm Res. 2018 Jul 9;35(9):174. doi: 10.1007/s11095-018-2456-8

Table I.

Estimated model parameters

	Value (RSD %)	Unit	Source

K_pp	2.2836	-	Calculated
Fr	0.18	-	(22)
Fra	1	-	Assumption
PER	0.0756	cm/h	Unpublished
K_d	0.13 (51.6)	μmol/mL	optimized
CL_renal	18	mL/h	optimized
CL_hepatic	199 (0.193)	mL/h	optimized
K_{p_lung}	3.38 (10.8)	-	optimized
K_{p_gut}	1.26 (11.4)	-	optimized
K_{p_spleen}	5.74 (7.90)	-	optimized
K_{p_liver}	10.9 (12.9)	-	optimized
K_{p_kidney}	5.91 (6.15)	-	optimized
K_{p_heart}	5.63 (11.7)	-	optimized
K_{p_plasma}	4.07 (30.8)	-	optimized
K_{p_others}	13.3 (57.6)	-	optimized
K_{p_tumor}	3.6 (11.3)	-	optimized