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. Author manuscript; available in PMC: 2019 Aug 8.
Published in final edited form as: Science. 2019 Feb 7;363(6427):eaat9931. doi: 10.1126/science.aat9931

Fig. 3. Identification of a microbiome-encoded enzyme responsible for BRV metabolism.

Fig. 3.

(A) BRV conversion to BVU by representative human gut isolates. (B) Log2 fold change of BRV and BVU concentrations of B. thetaiotaomicron transposon insertion mutants (blue, n = 1290) compared to media controls (grey, n = 83) after 24 h of incubation. Each point represents one strain, sorted along the x-axis in the same order in top (BRV) and bottom (BVU) panels. Mean fold changes and 95% prediction intervals for controls and strains are indicated by solid lines and shaded areas, respectively. (C) BRV conversion by B. thetaiotaomicron wildtype (n=4), bt4554 mutant (n=4), and complemented strains expressing bt4554 at different levels (n=8). In (A) and (C), lines and shaded areas depict the mean and STD of independent cultures (n=4–8).