Table 2.
Associations between meat intake and overall and colorectal cancer-specific survival after colorectal cancer diagnosis among stage I-III patients
| Quartile of pre-diagnostic meat intake (servings/day) | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Q1 |
Q2 |
Q3 |
Q4 |
Continuous meat intake (servings/day) |
≤Median5 |
>Median5 |
|||||||||
| HR | 95% CI | HR | 95% CI | HR | 95% CI | HR | 95% CI | Pfor trend | HR | 95% CI | HR | 95%CI | HR | 95% CI | |
| Overall survival | |||||||||||||||
| Red meat | |||||||||||||||
| n (deaths) | 1847 (433) | 1817 (437) | 1697 (381) | 1334 (319) | 3976 (914) | 2721 (656) | |||||||||
| Model 11 | 1.00 | Ref. | 1.07 | 0.94–1.23 | 1.04 | 0.91–1.20 | 1.14 | 0.99–1.32 | 0.10 | 1.11 | 1.02–1.21 | 1.00 | Ref. | 1.11 | 1.00–1.23 |
| Model 22 | 1.00 | Ref. | 1.06 | 0.93–1.21 | 1.02 | 0.89–1.17 | 1.08 | 0.93–1.26 | 0.35 | 1.08 | 0.99–1.18 | 1.00 | Ref. | 1.08 | 0.97–1.20 |
| Processed meat | |||||||||||||||
| n (deaths) | 1300 (292) | 2499 (569) | 1698 (406) | 946 (230) | 3824 (851) | 2621 (646) | |||||||||
| Model 11 | 1.00 | Ref. | 1.08 | 0.93–1.25 | 1.18 | 1.01–1.38 | 1.17 | 0.98–1.39 | 0.03 | 1.02 | 0.87–1.20 | 1.00 | Ref. | 1.16 | 1.04–1.29 |
| Model 22 | 1.00 | Ref. | 1.05 | 0.90–1.22 | 1.13 | 0.97–1.32 | 1.10 | 0.93–1.32 | 0.16 | 0.98 | 0.83–1.15 | 1.00 | Ref. | 1.12 | 1.01–1.25 |
| CRC-specific survival | |||||||||||||||
| Red meat | |||||||||||||||
| n (deaths) | 1845 (230) | 1813 (229) | 1695 (216) | 1334 (184) | 3976 (498) | 2721 (361) | |||||||||
| Model 13 | 1.00 | Ref. | 1.03 | 0.86–1.24 | 1.05 | 0.87–1.27 | 1.15 | 0.95–1.41 | 0.14 | 1.14 | 1.02–1.27 | 1.00 | Ref. | 1.12 | 0.97–1.29 |
| Model 24 | 1.00 | Ref. | 1.02 | 0.85–1.22 | 1.03 | 0.85–1.24 | 1.09 | 0.89–1.33 | 0.39 | 1.10 | 0.98–1.23 | 1.00 | Ref. | 1.08 | 0.94–1.25 |
| Processed meat | |||||||||||||||
| n (deaths) | 1300 (150) | 2494 (323) | 1698 (229) | 946 (126) | 3824 (467) | 2621 (361) | |||||||||
| Model 13 | 1.00 | Ref. | 1.11 | 0.90–1.36 | 1.23 | 1.00–1.52 | 1.18 | 0.93–1.50 | 0.10 | 1.08 | 0.87–1.32 | 1.00 | Ref. | 1.18 | 1.03–1.37 |
| Model 24 | 1.00 | Ref. | 1.08 | 0.88–1.33 | 1.18 | 0.96–1.46 | 1.11 | 0.87–1.42 | 0.27 | 1.02 | 0.83–1.26 | 1.00 | Ref. | 1.15 | 0.99–1.32 |
1
Model 1: adjusted for age at diagnosis, sex, cancer site, tumor stage; stratified by study and stage.
2
Model 2: adjusted for Model 1 plus BMI, smoking status, family history of colorectal cancer, aspirin/NSAIDs use, education
3
Model 1: adjusted for age at diagnosis, sex, cancer site, tumor stage, study; stratified by age categories
4
Model 2: adjusted for Model 1 plus BMI, smoking status, family history of colorectal cancer, aspirin/NSAIDs use, education
5
Study-specific medians
Abbreviations: CRC, colorectal cancer; HR, hazard ratio; CI, confidence interval.