2.

150例患者EGFR少见突变患者的临床病理特征

Clinical and pathological characteristic in 150 patients with EGFR rare mutations

Variable	All patients	18 G719X	21 L861Q	Other single mutations	Complex mutations	χ2	P
Gender
Male	53 (35.3%)	16 (34.8%)	14 (31.1%)	6 (42.9%)	17 (37.8%)	0.822	0.84
Female	97 (64.7%)	30 (65.2%)	31 (68.9%)	8 (57.1%)	28 (62.2%)
Age (yr)
＞60	85 (56.7%)	22 (47.8%)	29 (64.4%)	8 (57.1%)	26 (57.8%)	2.597	0.46
≤60	65 (43.3%)	24 (52.2%)	16 (35.6%)	6 (42.9%)	19 (42.2%)
Stage
Ⅰa-Ⅲa	14 (9.38%)	6 (13.0%)	1 (2.2%)	2 (14.3%)	5 (11.1%)	10.179	0.10
Ⅲb-Ⅳ	81 (54.0%)	28 (60.9%)	22 (48.9%)	5 (35.7%)	26 (57.8%)
NA	55 (36.7%)	12 (26.1%)	22 (48.9%)	7 (50.0%)	14 (31.1%)
Pathology
Adenocarcinoma	147 (98%)	45 (97.8%)	44 (97.8%)	14 (100.0%)	44 (97.8%)	0.769	1.00
Non-adenocarcinoma	3 (2.0%)	1 (2.2%)	1 (2.2%)	0 (0.0%)	1 (2.2%)
Smoking history
No	94 (62.7%)	27 (58.7%)	31 (68.9%)	7 (50.0%)	29 (64.4%)	3.037	0.81
Yes	24 (16.0%)	9 (19.6%)	6 (13.3%)	2 (14.3%)	7 (15.6%)
NA	32 (21.3%)	10 (21.7%)	8 (17.8%)	5	9 (20.0%)