Table 2.
Regions |
VT (ml/cm3) |
SUV |
||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
[18F]FP-(+)-DTBZ |
[18F]FP-(−)-DTBZ |
[18F]FP-(+)-DTBZ |
[18F]FP-(−)-DTBZ |
|||||||||
HC | T1DM | P value | HC | T1DM | P value | HC | T1DM | P value | HC | T1DM | P value | |
Pancreas | 166 ± 48 | 96 ± 37 | 0.04 | 24 ± 3 | 18 ±5 | 0.06 | 22.6 ± 3.6 | 9.9 ± 5.4 | 0.002 | 6.1 ± 1.1 | 3.9 ±1.5 | 0.03 |
Spleen | 27 ±2 | 31 ±5 | 0.19 | 9±2 | 9±3 | 0.72 | 4.3 ± 0.7 | 3.7 ± 2.1 | 0.47 | 2.1 ±0.5 | 1.7 ±0.5 | 0.22 |
Renal cortex | 23 ±3 | 21 ±4 | 0.22 | 10 ±2 | 10 ±2 | 0.98 | 3.5 ± 0.7 | 2.3 ± 1.0 | 0.05 | 2.6 ± 0.4 | 2.0 ± 0.6 | 0.07 |
Vt values were derived from the MA1 model, and SUVs were calculated from 60 to 120 min post injection. Values are expressed as mean±SD for healthy controls (HC, n = 6) and T1DM patients (n = 4). Group differences were tested using the t test